Vol. 4 No. 4 (2026): RICOS BIOLOGY JOURNAL issue April, 2026
From the Editor
The immune system is a study in paradoxes—a tireless guardian that can also turn traitor, a localized force with systemic consequences, and a network whose evolution has been shaped as much by parasites as by pathogens. The April 2025 issue of Ricos Biology Journal explores this fascinating duality across the full spectrum of host defense. Our Review Articles navigate cutting-edge terrain, from modern strategies for canine fracture-related osteomyelitis to the "Western anaphylaxis paradox," where helminth-driven IgE modulation may explain allergy resistance in agrarian societies. We also introduce a compelling hypothesis on multi-antibiotic synergy for optimized infection control, alongside comprehensive surveys of passive immunotherapy in systemic lupus erythematosus and the emerging role of NSAIDs in autoimmune disease management. To ground these advanced topics, our Educational Notes return to fundamentals—re-examining physical and mechanical barriers in innate immunity, as well as the core components of the immune system. Together, these contributions bridge the gap between basic principles and tomorrow’s therapeutics, reminding us that understanding immunity requires both a microscope and a global lens. Welcome to the April issue.

